Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: A pilot study" by Holzer G, Grasse AV, Zehetmayer S, Bencur P, Bieglmayer C, Mannhalter C., posted in US National Library of Medicine National Institutes of Health, researchers indicated that The reduction of vitamin K to vitamin K hydrochinon depends on the vitamin K epoxide reductase complex subunit 1 (VKORC1). We evaluated the impact of polymorphisms in VKORC1 on BMD and fractures... and concluded that in our cohort, a genetic variation in the 3'-region of the VKORC1 gene (9041 AG and GG) was associated significantly with low BMD. This finding suggests that VKORC1 may play a role in osteoporosis. The results of our pilot study should be confirmed as our findings may be important for treatment decisions.