Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "White centered retinal hemorrhages in vitamin b(12) deficiency anemia" by Zehetner C, Bechrakis NE., posted in US National Library of Medicine National Institutes of Health, researcher indicated that in megaloblastic anemia, direct anoxia results in endothelial dysfunction. The loss of impermeability allows extrusion of whole blood and subsequent diffusion from the disrupted site throughout and above the nerve fiber layer. Therefore the biomicroscopic pattern of white centered hemorrhages observed in anemic retinopathy is most likely due to the clot formation as the reparative sequence after capillary rupture.
Saturday, November 19, 2011
Folic acid and Cognitive function
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people" by Malouf R, Grimley Evans J., posted in US National Library of Medicine National Institutes of Health, researchers found that In a preliminary study, folic acid was associated with improvement in the response of people with Alzheimer's disease to cholinesterase inhibitors. In another, long-term use appeared to improve the cognitive function of healthy older people with high homocysteine levels. More studies are needed on
In the study of "Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people" by Malouf R, Grimley Evans J., posted in US National Library of Medicine National Institutes of Health, researchers found that In a preliminary study, folic acid was associated with improvement in the response of people with Alzheimer's disease to cholinesterase inhibitors. In another, long-term use appeared to improve the cognitive function of healthy older people with high homocysteine levels. More studies are needed on
Folate (vitamin B9) and vitamin B12 and the maintenance of nuclear and mitochondrial genome integrity
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of "Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity' by Fenech M.,posted in US National Library of Medicine National Institutes of Health, researcher found that show that folate and/or vitamin B12 deficiency and elevated plasma homocysteine (a metabolic indicator of folate deficiency) are significantly correlated with increased micronucleus formation and reduced telomere length respectively. In vitro experiments indicate that genomic instability in human cells is minimised when folic acid concentration in culture medium is greater than 100nmol/L.
According to the study of "Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity' by Fenech M.,posted in US National Library of Medicine National Institutes of Health, researcher found that show that folate and/or vitamin B12 deficiency and elevated plasma homocysteine (a metabolic indicator of folate deficiency) are significantly correlated with increased micronucleus formation and reduced telomere length respectively. In vitro experiments indicate that genomic instability in human cells is minimised when folic acid concentration in culture medium is greater than 100nmol/L.
Folate and Liver Cancer
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of "Molecular alterations in hepatocarcinogenesis induced by dietary methyl deficiency" by Pogribny IP, James SJ, Beland FA., posted in US National Library of Medicine National Institutes of Health, researchers found that Feeding methyl-deficient diets causes several molecular alterations that can lead to progressive liver injury culminating in the development of primary liver tumors.
According to the study of "Molecular alterations in hepatocarcinogenesis induced by dietary methyl deficiency" by Pogribny IP, James SJ, Beland FA., posted in US National Library of Medicine National Institutes of Health, researchers found that Feeding methyl-deficient diets causes several molecular alterations that can lead to progressive liver injury culminating in the development of primary liver tumors.
Vitamin B12 and Liver Cancer
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Molecular alterations in hepatocarcinogenesis induced by dietary methyl deficiency" by Pogribny IP, James SJ, Beland FA., posted in US National Library of Medicine National Institutes of Health, researchers found that Feeding methyl-deficient diets causes several molecular alterations, including altered lipid metabolism, oxidative stress, deregulated one-carbon metabolism, and a number of epigenetic abnormalities that result in progressive liver injury culminating in the development of primary liver tumors.
In the study of "Molecular alterations in hepatocarcinogenesis induced by dietary methyl deficiency" by Pogribny IP, James SJ, Beland FA., posted in US National Library of Medicine National Institutes of Health, researchers found that Feeding methyl-deficient diets causes several molecular alterations, including altered lipid metabolism, oxidative stress, deregulated one-carbon metabolism, and a number of epigenetic abnormalities that result in progressive liver injury culminating in the development of primary liver tumors.
Tuesday, November 15, 2011
vitamin E and Nonalcoholic steatohepatitis
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
Acccording to the study of "Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis" by
Acccording to the study of "Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis" by
Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, Neuschwander-Tetri BA, Lavine JE, Tonascia J, Unalp A, Van Natta M, Clark J, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR; NASH CRN., posted in US National Library of Medicine National Institutes of Health, researchers indicated that Vitamin E was superior to placebo for the treatment of nonalcoholic steatohepatitis in adults without diabetes. There was no benefit of pioglitazone over placebo for the primary outcome; however, significant benefits of pioglitazone were observed for some of the secondary outcomes.
Vitamin E and Multiple cardiovascular risk factors
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of "Effect of long-term treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors" by Shargorodsky M, Debby O, Matas Z, Zimlichman R., posted in US National Library of Medicine National Institutes of Health, researchers found that antioxidant supplementation significantly increased large and small artery elasticity in patients with multiple cardiovascular risk factors. This beneficial vascular effect was associated with an improvement in glucose and lipid metabolism as well as decrease in blood pressure.
According to the study of "Effect of long-term treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors" by Shargorodsky M, Debby O, Matas Z, Zimlichman R., posted in US National Library of Medicine National Institutes of Health, researchers found that antioxidant supplementation significantly increased large and small artery elasticity in patients with multiple cardiovascular risk factors. This beneficial vascular effect was associated with an improvement in glucose and lipid metabolism as well as decrease in blood pressure.
Vitamin E and Chronic recurrent viral mucocutaneous infections
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral mucocutaneous infections" by De Luca C, Kharaeva Z, Raskovic D, Pastore P, Luci A, Korkina L., posted in US National Library of Medicine National Institutes of Health, researchers found that the nutriceutical induced significantly faster healing (P < 0.01-0.05) with reduced incidence of relapses (P < 0.05) as compared to control groups, which was confirmed by decreased viral load and increased antiviral cytokine and peroxynitrite plasma levels. Plasma antioxidant capacity was higher (P < 0.01) in the experimental versus control groups.
In the study of "Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral mucocutaneous infections" by De Luca C, Kharaeva Z, Raskovic D, Pastore P, Luci A, Korkina L., posted in US National Library of Medicine National Institutes of Health, researchers found that the nutriceutical induced significantly faster healing (P < 0.01-0.05) with reduced incidence of relapses (P < 0.05) as compared to control groups, which was confirmed by decreased viral load and increased antiviral cytokine and peroxynitrite plasma levels. Plasma antioxidant capacity was higher (P < 0.01) in the experimental versus control groups.
Wednesday, November 9, 2011
Vitamin D and inflammation.
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Vitamin D and inflammation" by Guillot X, Semerano L, Saidenberg-Kermanac'h N, Falgarone G, Boissier MC., posted in US National Library of Medicine National Institutes of Health, researchers found that The immunomodulating effects of vitamin D may explain the reported epidemiological associations between vitamin D status and a large number of autoimmune and inflammatory diseases. Such associations have been suggested by observational studies not only in rheumatoid arthritis, lupus, inflammatory bowel disease, and type 1 diabetes; but also in infections, malignancies, transplant rejection, and cardiovascular disease
In the study of "Vitamin D and inflammation" by Guillot X, Semerano L, Saidenberg-Kermanac'h N, Falgarone G, Boissier MC., posted in US National Library of Medicine National Institutes of Health, researchers found that The immunomodulating effects of vitamin D may explain the reported epidemiological associations between vitamin D status and a large number of autoimmune and inflammatory diseases. Such associations have been suggested by observational studies not only in rheumatoid arthritis, lupus, inflammatory bowel disease, and type 1 diabetes; but also in infections, malignancies, transplant rejection, and cardiovascular disease
Vitmain D and Inflammation and Allgeric Response??
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of "Regulatory T cells, inflammation and the allergic response-The role of glucocorticoids and Vitamin D" by Dimeloe S, Nanzer A, Ryanna K, Hawrylowicz C., posted in US National Library of Medicine National Institutes of Health, researchers found that the role of glucocorticoids and Vitamin D, and their potential interactions in promoting tolerance in the context of allergic disease and asthma.
According to the study of "Regulatory T cells, inflammation and the allergic response-The role of glucocorticoids and Vitamin D" by Dimeloe S, Nanzer A, Ryanna K, Hawrylowicz C., posted in US National Library of Medicine National Institutes of Health, researchers found that the role of glucocorticoids and Vitamin D, and their potential interactions in promoting tolerance in the context of allergic disease and asthma.
The role of Vitamin A in tolerance and immunity??
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of "The role of retinoic acid in tolerance and immunity" by Hall JA, Grainger JR, Spencer SP, Belkaid Y., posted in US National Library of Medicine National Institutes of Health, researchers indicated that we will prvide a crucial contributions of RA to both immunological tolerance and the elicitation of adaptive immune responses and acomprehensive overview of the cell types and factors that control the production of RA and discuss how host perturbations may affect the ability of this metabolite to control tolerance and immunity or to instigate pathology.
According to the study of "The role of retinoic acid in tolerance and immunity" by Hall JA, Grainger JR, Spencer SP, Belkaid Y., posted in US National Library of Medicine National Institutes of Health, researchers indicated that we will prvide a crucial contributions of RA to both immunological tolerance and the elicitation of adaptive immune responses and acomprehensive overview of the cell types and factors that control the production of RA and discuss how host perturbations may affect the ability of this metabolite to control tolerance and immunity or to instigate pathology.
Friday, November 4, 2011
Vitamin D and Cardiovascular diseases
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of `Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular event` by Wang L, Manson JE, Song Y, Sesso HD., posted in US National Library of Medicine National Institutes of Health, researcher found that evidence from limited data suggests that vitamin D supplements at moderate to high doses may reduce CVD risk, whereas calcium supplements seem to have minimal cardiovascular effects. Further research is needed to elucidate the role of these supplements in CVD prevention.
In the study of `Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular event` by Wang L, Manson JE, Song Y, Sesso HD., posted in US National Library of Medicine National Institutes of Health, researcher found that evidence from limited data suggests that vitamin D supplements at moderate to high doses may reduce CVD risk, whereas calcium supplements seem to have minimal cardiovascular effects. Further research is needed to elucidate the role of these supplements in CVD prevention.
Vitamin D and allergic diseases
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of `Vitamin D in atopic dermatitis, asthma and allergic diseases`by Searing DA, Leung DY., posted in US National Library of Medicine National Institutes of Health, researchers found that laboratory evidence supporting links between vitamin D deficiency and allergic diseases, the clinical evidence for and against vitamin D playing a role in allergic diseases, and the emerging evidence regarding the potential use of vitamin D to augment the innate immune response in atopic dermatitis are reviewed.
According to the study of `Vitamin D in atopic dermatitis, asthma and allergic diseases`by Searing DA, Leung DY., posted in US National Library of Medicine National Institutes of Health, researchers found that laboratory evidence supporting links between vitamin D deficiency and allergic diseases, the clinical evidence for and against vitamin D playing a role in allergic diseases, and the emerging evidence regarding the potential use of vitamin D to augment the innate immune response in atopic dermatitis are reviewed.
Vitamin A and Cervical cancer
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of `Vitamin A and risk of cervical cancer: A meta-analysis`by Zhang X, Dai B, Zhang B, Wang Z., posted in US National Library of Medicine National Institutes of Health, researchers found that Vitamin A intake and blood vitamin A levels were inversely associated with the risk of cervical cancer
According to the study of `Vitamin A and risk of cervical cancer: A meta-analysis`by Zhang X, Dai B, Zhang B, Wang Z., posted in US National Library of Medicine National Institutes of Health, researchers found that Vitamin A intake and blood vitamin A levels were inversely associated with the risk of cervical cancer
Wednesday, November 2, 2011
vitamin D and muscle atrophy
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of "Serum 25-hydroxyvitamin D and muscle atrophy in the elderly" by Dawson-Hughes B., posted in US National Library of Medicine National Institutes of Health, researcher found that doses up through 15 μg (600 IU) were ineffective and doses of 17·5-25 μg/d (700-1000 IU/d) significantly lowered fall risk. The minimal 25-hydroxyvitamin D level needed for benefit was 60 nmol/l.
According to the study of "Serum 25-hydroxyvitamin D and muscle atrophy in the elderly" by Dawson-Hughes B., posted in US National Library of Medicine National Institutes of Health,
Vitamin D and prevention of periodontal ligament
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of "1α,25-Dihydroxyvitamin D3 inhibits osteoblastic differentiation of mouse periodontal fibroblasts" by Chen YC, Ninomiya T, Hosoya A, Hiraga T, Miyazawa H, Nakamura H, posted in US National Library of Medicine National Institutes of Health, researchers found that VD(3) negatively regulates the osteoblastic differentiation of mouse periodontal fibroblasts and prevents the periodontal ligament from mineralization via increase of PLAP-1.
According to the study of "1α,25-Dihydroxyvitamin D3 inhibits osteoblastic differentiation of mouse periodontal fibroblasts" by Chen YC, Ninomiya T, Hosoya A, Hiraga T, Miyazawa H, Nakamura H, posted in US National Library of Medicine National Institutes of Health, researchers found that VD(3) negatively regulates the osteoblastic differentiation of mouse periodontal fibroblasts and prevents the periodontal ligament from mineralization via increase of PLAP-1.
Vitamin D and lung inflammatory factors
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "[Effect of early Vitamin D supplementation on lung inflammatory factors in baby rat with asthma].[Article in Chinese]" by Liu PY, Chen X, Jiang ZQ, Leng L, Wang XQ, Ji GY. by US National Library of Medicine National Institutes of Health, researchers found that Intervention with appropriate dose of 1,25-(OH)(2)VitD(3) in the early life could improve lung pathologic changes and reduce the effect of inflammatory factors in air way of baby rat asthma model. However, overdose might play detrimental effect.
In the study of "[Effect of early Vitamin D supplementation on lung inflammatory factors in baby rat with asthma].[Article in Chinese]" by Liu PY, Chen X, Jiang ZQ, Leng L, Wang XQ, Ji GY. by US National Library of Medicine National Institutes of Health, researchers found that Intervention with appropriate dose of 1,25-(OH)(2)VitD(3) in the early life could improve lung pathologic changes and reduce the effect of inflammatory factors in air way of baby rat asthma model. However, overdose might play detrimental effect.
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