Wednesday, October 12, 2011

Vitamin C and Colon Cancer

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

According to the study of "Pharmacologic doses of ascorbic Acid repress specificity protein (sp) transcription factors and sp-regulated genes in colon cancer cells" by Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S., posted in US National Library of Medicine National Institutes of Health, researchers wrote that ascorbic acid decreased expression of several Sp-regulated genes that are involved in cancer cell proliferation [hepatocyte growth factor receptor (c-Met), epidermal growth factor receptor and cyclin D1], survival (survivin and bcl-2), and angiogenesis [vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2)].

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