Tuesday, October 25, 2011

Vitamin K and Fracture prevention

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study of "Vitamin K: fracture prevention and beyond" by Falcone TD, Kim SS, Cortazzo MH.., posted in US National Library of Medicine National Institutes of Health, researchers found that Vitamin K is essential to bone physiology and prevention of atherosclerosis. It is involved in bone remodeling, cell signaling, apoptosis, arterial calcification, and chemotaxis, and it has anti-inflammatory effects. Conversely, warfarin, a potent vitamin K inhibitor, has demonstrated adverse effects on bone remodeling and atherosclerosis. Natural forms of vitamin K are available in multiple dietary sources, and some structural forms are more readily available for use in metabolic pathways than are others. With regard to supplementation, the specific form of vitamin K is often not disclosed, and the recommended daily value is potentially less than what is physiologically required. On the basis of a review of the literature, it appears advantageous to encourage patients to eat a diet rich in vitamin K; however, the benefit of vitamin K supplementation alone is yet to be thoroughly conveyed.

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