Friday, October 21, 2011

Vitamin B12 and Neurotrophic action

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

According to the study of "Epidermal growth factor as a local mediator of the neurotrophic action of vitamin B(12) (cobalamin) in the rat central nervous system" by Scalabrino G, Nicolini G, Buccellato FR, Peracchi M, Tredici G, Manfridi A, Pravettoni G., posted in US National Library of Medicine National Institutes of Health, researchers wrote that this in vivo study presents the first evidence that the neurotrophic action of Cbl in the CNS of TGX rats is mediated by stimulation of the EGF synthesis in the CNS itself. It thus appears that Cbl inversely regulates the expression of EGF and TNF-alpha genes in the CNS of TGX rats.

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