Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Impact of massive ascorbic acid supplementation on alcohol induced oxidative stress in guinea pigs" by Suresh MV, Sreeranjit Kumar CV, Lal JJ, Indira M., posted in US National Library of Medicine National Institutes of Health, found that Administration of ascorbic acid also reduced the activity of gamma-glutamyl transpeptidase (GGT), the marker enzyme of alcohol induced toxicity. The vitamin E level, which was reduced by alcohol intake, was raised by the co-administration of AA and alcohol. These studies suggest that a mega dose of AA helps in the prevention of alcohol induced oxidative stress by enhancing the antioxidant capacity and also by reducing the lipid peroxidation products.
Saturday, December 17, 2011
vitamin C and cellular energy metabolism.
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Vitamin C deficiency activates the purine nucleotide cycle in zebrafish" by Kirkwood JS, Lebold KM, Miranda CL, Wright CL, Miller GW, Tanguay RL, Barton CL, Traber MG, Stevens JF., posted in US National Library of Medicine National Institutes of Health, found that irreversibly deaminates AMP to form IMP. We found a 47% increase in AMPD activity in the AA deficient zebrafish, complementary to the 44-fold increase in IMP concentration. These results suggest that vitamin C is crucial for the maintenance of cellular energy metabolism.
In the study of "Vitamin C deficiency activates the purine nucleotide cycle in zebrafish" by Kirkwood JS, Lebold KM, Miranda CL, Wright CL, Miller GW, Tanguay RL, Barton CL, Traber MG, Stevens JF., posted in US National Library of Medicine National Institutes of Health, found that irreversibly deaminates AMP to form IMP. We found a 47% increase in AMPD activity in the AA deficient zebrafish, complementary to the 44-fold increase in IMP concentration. These results suggest that vitamin C is crucial for the maintenance of cellular energy metabolism.
Vitamin C and iron-refractory iron deficiency anemia (IRIDA).
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Responsiveness to oral iron and ascorbic acid in a patient with IRIDA" by Cau M, Galanello R, Giagu N, Melis MA., posted in US National Library of Medicine National Institutes of Health, reported that a female infant homozygous for a loss of function mutation in TMPRSS6 gene, who responded to oral iron therapy when supplemented with ascorbic acid.
In the study of "Responsiveness to oral iron and ascorbic acid in a patient with IRIDA" by Cau M, Galanello R, Giagu N, Melis MA., posted in US National Library of Medicine National Institutes of Health, reported that a female infant homozygous for a loss of function mutation in TMPRSS6 gene, who responded to oral iron therapy when supplemented with ascorbic acid.
Vitamin C and Glaucoma.
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Association between a SLC23A2 gene variation, plasma vitamin C levels, and risk of glaucoma in a Mediterranean population" by Zanon-Moreno V, Ciancotti-Olivares L, Asencio J, Sanz P, Ortega-Azorin C, Pinazo-Duran MD, Corella D., posted in US National Library of Medicine National Institutes of Health, found that The rs1279683 single-nucleotide polymorphisms (SNPs) in SLC23A2 was significantly associated with lower plasma concentrations of vitamin C and with higher risk of primary open-angle glaucoma (POAG) in the G allele (GG subjects) subjects.
In the study of "Association between a SLC23A2 gene variation, plasma vitamin C levels, and risk of glaucoma in a Mediterranean population" by Zanon-Moreno V, Ciancotti-Olivares L, Asencio J, Sanz P, Ortega-Azorin C, Pinazo-Duran MD, Corella D., posted in US National Library of Medicine National Institutes of Health, found that The rs1279683 single-nucleotide polymorphisms (SNPs) in SLC23A2 was significantly associated with lower plasma concentrations of vitamin C and with higher risk of primary open-angle glaucoma (POAG) in the G allele (GG subjects) subjects.
Vitamin C deficiency and chronic ultraviolet-B exposure
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "The effect of vitamin C deficiency and chronic ultraviolet-B exposure on corneal ultrastructure: a preliminary investigation" by Hayes S, Cafaro TA, Boguslawska PJ, Kamma-Lorger CS, Boote C, Harris J, Young R, Hiller J, Terrill N, Meek KM, Serra HM., posted in US National Library of Medicine National Institutes of Health, found that UVB-induced changes in the corneal ultrastructure were most pronounced in animals fed an ascorbic acid-deficient diet. This suggests that ascorbic acid may play a vital role in protecting the corneal stroma from the harmful effects of UVB.
In the study of "The effect of vitamin C deficiency and chronic ultraviolet-B exposure on corneal ultrastructure: a preliminary investigation" by Hayes S, Cafaro TA, Boguslawska PJ, Kamma-Lorger CS, Boote C, Harris J, Young R, Hiller J, Terrill N, Meek KM, Serra HM., posted in US National Library of Medicine National Institutes of Health, found that UVB-induced changes in the corneal ultrastructure were most pronounced in animals fed an ascorbic acid-deficient diet. This suggests that ascorbic acid may play a vital role in protecting the corneal stroma from the harmful effects of UVB.
Monday, December 12, 2011
Life-threatening thiamine deficiency in infants
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Outbreak of life-threatening thiamine deficiency in infants in Israel caused by a defective soy-based formula" by Fattal-Valevski A, Kesler A, Sela BA, Nitzan-Kaluski D, Rotstein M, Mesterman R, Toledano-Alhadef H, Stolovitch C, Hoffmann C, Globus O, Eshel G., posted in US National Library of Medicine National Institutes of Health, indicated that Clinician awareness of the possibility of thiamine deficiency even in well-nourished infants is important for early recognition and prevention of irreversible brain damage. Therapy with large doses of thiamine should be initiated at the earliest suspicion of vitamin depletion, even before laboratory evidence is available and before neurologic or cardiologic symptoms appear.
In the study of "Outbreak of life-threatening thiamine deficiency in infants in Israel caused by a defective soy-based formula" by Fattal-Valevski A, Kesler A, Sela BA, Nitzan-Kaluski D, Rotstein M, Mesterman R, Toledano-Alhadef H, Stolovitch C, Hoffmann C, Globus O, Eshel G., posted in US National Library of Medicine National Institutes of Health, indicated that Clinician awareness of the possibility of thiamine deficiency even in well-nourished infants is important for early recognition and prevention of irreversible brain damage. Therapy with large doses of thiamine should be initiated at the earliest suspicion of vitamin depletion, even before laboratory evidence is available and before neurologic or cardiologic symptoms appear.
Thiamine and acid tolerance of Listeria monocytogenes.
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Thiamine plays a critical role in the acid tolerance of Listeria monocytogenes" by Madeo M, O'Riordan N, Fuchs TM, Utratna M, Karatzas KA, O'Byrne CP., posted in US National Library of Medicine National Institutes of Health, found that Thiamine-depleted cultures failed to produce significant concentrations of acetoin, consistent with the known thiamine dependence of acetolactate synthase, an enzyme required for acetoin synthesis from pyruvate. As acetoin synthesis is a proton-consuming process, we suggest that the acid sensitivity observed in thiamine-depleted cultures may be owing to an inability to produce acetoin.
In the study of "Thiamine plays a critical role in the acid tolerance of Listeria monocytogenes" by Madeo M, O'Riordan N, Fuchs TM, Utratna M, Karatzas KA, O'Byrne CP., posted in US National Library of Medicine National Institutes of Health, found that Thiamine-depleted cultures failed to produce significant concentrations of acetoin, consistent with the known thiamine dependence of acetolactate synthase, an enzyme required for acetoin synthesis from pyruvate. As acetoin synthesis is a proton-consuming process, we suggest that the acid sensitivity observed in thiamine-depleted cultures may be owing to an inability to produce acetoin.
Vitamin B and dyslipidemia and Advanced glycation of plasma protein
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats" by Karachalias N, Babaei-Jadidi R, Kupich C, Ahmed N, Thornalley PJ., posted in US National Library of Medicine National Institutes of Health, found that the reversal of thiamine deficiency by high-dose thiamine and S-benzoylthiamine monophosphate (benfotiamine) prevented the development of incipient nephropathy. Recently, we reported that high-dose thiamine (but not benfotiamine) countered diabetic dyslipidemia.
In the study of "High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats" by Karachalias N, Babaei-Jadidi R, Kupich C, Ahmed N, Thornalley PJ., posted in US National Library of Medicine National Institutes of Health, found that the reversal of thiamine deficiency by high-dose thiamine and S-benzoylthiamine monophosphate (benfotiamine) prevented the development of incipient nephropathy. Recently, we reported that high-dose thiamine (but not benfotiamine) countered diabetic dyslipidemia.
Vitamin B1 and diabetic complications
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "The potential role of thiamine (vitamin B1) in diabetic complications" by Thornalley PJ., post in posted in US National Library of Medicine National Institutes of Health, found that Dysfunction of beta-cells and impaired glucose tolerance in thiamine deficiency and suggestion of a link of impaired glucose tolerance with dietary thiamine indicates that thiamine therapy may have a future role in prevention of type 2 diabetes. More immediately, given the emerging multiple benefits of thiamine repletion, even mild thiamine deficiency in diabetes should be avoided and thiamine supplementation to high dose should be considered as adjunct nutritional therapy to prevent dyslipidemia and the development of vascular complications in clinical diabetes.
In the study of "The potential role of thiamine (vitamin B1) in diabetic complications" by Thornalley PJ., post in posted in US National Library of Medicine National Institutes of Health, found that Dysfunction of beta-cells and impaired glucose tolerance in thiamine deficiency and suggestion of a link of impaired glucose tolerance with dietary thiamine indicates that thiamine therapy may have a future role in prevention of type 2 diabetes. More immediately, given the emerging multiple benefits of thiamine repletion, even mild thiamine deficiency in diabetes should be avoided and thiamine supplementation to high dose should be considered as adjunct nutritional therapy to prevent dyslipidemia and the development of vascular complications in clinical diabetes.
Vitamin B1 and Diastolic dysfunction and heart failure
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway" by Katare RG, Caporali A, Oikawa A, Meloni M, Emanueli C, Madeddu P., posted in US National Library of Medicine National Institutes of Health, found that vitamin B1 analog benfotiamine (BFT) protects from diabetes mellitus-induced cardiac dysfunction through pleiotropic mechanisms, culminating in the activation of prosurvival signaling pathway. Thus, BFT merits attention for application in clinical practice.
In the study of "Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway" by Katare RG, Caporali A, Oikawa A, Meloni M, Emanueli C, Madeddu P., posted in US National Library of Medicine National Institutes of Health, found that vitamin B1 analog benfotiamine (BFT) protects from diabetes mellitus-induced cardiac dysfunction through pleiotropic mechanisms, culminating in the activation of prosurvival signaling pathway. Thus, BFT merits attention for application in clinical practice.
Thursday, December 8, 2011
Vitamin K and Testosterone production
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells" by Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai M., posted in US National Library of Medicine National Institutes of Health, found that menaquinone-4 (MK-4, 75 mg/kg diet), one of the predominant K₂ vitamins stimulates testosterone production in rats and testis-derived tumor cells via activation of PKA. MK-4 may be involved in steroidogenesis in the testis, and its supplementation could reverse the downregulation of testosterone production in elders.
In the study of "Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells" by Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai M., posted in US National Library of Medicine National Institutes of Health, found that menaquinone-4 (MK-4, 75 mg/kg diet), one of the predominant K₂ vitamins stimulates testosterone production in rats and testis-derived tumor cells via activation of PKA. MK-4 may be involved in steroidogenesis in the testis, and its supplementation could reverse the downregulation of testosterone production in elders.
Vitamin D-vitamin K interaction:
In the study of "Vitamin D-vitamin K interaction: effect of vitamin D supplementation on serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, in Danish girls" by O'Connor E, Mølgaard C, Michaelsen KF, Jakobsen J, Cashman KD., posted in US National Library of Medicine National Institutes of Health, found that Vitamin D3 supplementation significantly increased serum 25(OH)D (21.6 %; P < 0.002) but had no effect on serum %ucOC (P>0.8). In conclusion, the findings of the present intervention study in young girls suggest that vitamin D supplementation does not affect serum %ucOC, a marker of vitamin K status.
Vitamin K and Bone mineral density
In the study of " Vitamin K, circulating cytokines, and bone mineral density in older men and women" by Shea MK, Dallal GE, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Gundberg CM, Peterson JW, Booth SL., posted in US National Library of Medicine National Institutes of Health, found that Poor vitamin K status was associated with high concentrations of cytokines involved in bone turnover, but vitamin K supplementation did not confer a decrease in cytokine concentrations. The healthy status of this cohort may explain a lack of effect of vitamin K supplementation on cytokine concentrations.
Vitamin K supplementation and progression of Coronary artery calcification
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Vitamin K supplementation and progression of coronary artery calcium in older men and women" by Shea MK, O'Donnell CJ, Hoffmann U, Dallal GE, Dawson-Hughes B, Ordovas JM, Price PA, Williamson MK, Booth SL., posted in US National Library of Medicine National Institutes of Health, found that phylloquinone supplementation slows the progression of Coronary artery calcification (CAC) in healthy older adults with preexisting CAC, independent of its effect on total matrix Gla protein (MGP) concentrations. Because our data are hypothesis-generating, further studies are warranted to clarify this mechanism.
In the study of "Vitamin K supplementation and progression of coronary artery calcium in older men and women" by Shea MK, O'Donnell CJ, Hoffmann U, Dallal GE, Dawson-Hughes B, Ordovas JM, Price PA, Williamson MK, Booth SL., posted in US National Library of Medicine National Institutes of Health, found that phylloquinone supplementation slows the progression of Coronary artery calcification (CAC) in healthy older adults with preexisting CAC, independent of its effect on total matrix Gla protein (MGP) concentrations. Because our data are hypothesis-generating, further studies are warranted to clarify this mechanism.
Vitamin K and Osteopenia
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial" by Cheung AM, Tile L, Lee Y, Tomlinson G, Hawker G, Scher J, Hu H, Vieth R, Thompson L, Jamal S, Josse R., posted in US National Library of Medicine National Institutes of Health, found that daily 5 mg of vitamin K1 supplementation for 2 to 4 y does not protect against age-related decline in BMD, but may protect against fractures and cancers in postmenopausal women with osteopenia. More studies are needed to further examine the effect of vitamin K on fractures and cancers.
In the study of "Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial" by Cheung AM, Tile L, Lee Y, Tomlinson G, Hawker G, Scher J, Hu H, Vieth R, Thompson L, Jamal S, Josse R., posted in US National Library of Medicine National Institutes of Health, found that daily 5 mg of vitamin K1 supplementation for 2 to 4 y does not protect against age-related decline in BMD, but may protect against fractures and cancers in postmenopausal women with osteopenia. More studies are needed to further examine the effect of vitamin K on fractures and cancers.
Wednesday, December 7, 2011
Vitamin K antagonists and children with heart diseases
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Vitamin K antagonists in children with heart diseases: height and VKORC1 genotype are the main determinants of the warfarin dose requirement" by Moreau C, Bajolle F, Siguret V, Lasne D, Golmard JL, Elie C, Beaune P, Cheurfi R, Bonnet D, Loriot MA., posted in US National Library of Medicine National Institutes of Health, found that height, target INR, VKORC1 and CYP2C9 genotypes were the main determinants of warfarin dose requirement, accounting for 48.1%, 4.4%, 18.2% and 2.0%, respectively, and explaining 69.7% of the variability. Our model predicted the warfarin dose within 7mg/week in 86.7% of patients. None of the covariates were associated with the time spent above or below the INR range. Whether this model predicts accurately the effective maintenance dose is currently investigated.
In the study of "Vitamin K antagonists in children with heart diseases: height and VKORC1 genotype are the main determinants of the warfarin dose requirement" by Moreau C, Bajolle F, Siguret V, Lasne D, Golmard JL, Elie C, Beaune P, Cheurfi R, Bonnet D, Loriot MA., posted in US National Library of Medicine National Institutes of Health, found that height, target INR, VKORC1 and CYP2C9 genotypes were the main determinants of warfarin dose requirement, accounting for 48.1%, 4.4%, 18.2% and 2.0%, respectively, and explaining 69.7% of the variability. Our model predicted the warfarin dose within 7mg/week in 86.7% of patients. None of the covariates were associated with the time spent above or below the INR range. Whether this model predicts accurately the effective maintenance dose is currently investigated.
Vitamin K antagonists and prevention of thromboembolism
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Comparison of idraparinux with vitamin K antagonists for prevention of thromboembolism in patients with atrial fibrillation: a randomised, open-label, non-inferiority trial" by Amadeus Investigators, Bousser MG, Bouthier J, Büller HR, Cohen AT, Crijns H, Davidson BL, Halperin J, Hankey G, Levy S, Pengo V, Prandoni P, Prins MH, Tomkowski W, Torp-Pedersen C, Wyse DG., posted in US National Library of Medicine National Institutes of Health, found that in patients with atrial fibrillation at risk for thromboembolism, long-term treatment with idraparinux was no worse than vitamin K antagonists in terms of efficacy, but caused significantly more bleeding.
In the study of "Comparison of idraparinux with vitamin K antagonists for prevention of thromboembolism in patients with atrial fibrillation: a randomised, open-label, non-inferiority trial" by Amadeus Investigators, Bousser MG, Bouthier J, Büller HR, Cohen AT, Crijns H, Davidson BL, Halperin J, Hankey G, Levy S, Pengo V, Prandoni P, Prins MH, Tomkowski W, Torp-Pedersen C, Wyse DG., posted in US National Library of Medicine National Institutes of Health, found that in patients with atrial fibrillation at risk for thromboembolism, long-term treatment with idraparinux was no worse than vitamin K antagonists in terms of efficacy, but caused significantly more bleeding.
Vitamin K antagonists
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Stroke prevention in atrial fibrillation: do we still need warfarin?" by Diener HC, Weber R, Lip GY, Hohnloser SH., posted in US National Library of Medicine National Institutes of Health, found that new anticoagulants add to the therapeutic options for patients with atrial fibrillation, and offer a number of advantages over warfarin, for both the clinician and patient, including a favourable bleeding profile and convenience of use. Consideration of these new anticoagulants will improve clinical decision making
In the study of "Stroke prevention in atrial fibrillation: do we still need warfarin?" by Diener HC, Weber R, Lip GY, Hohnloser SH., posted in US National Library of Medicine National Institutes of Health, found that new anticoagulants add to the therapeutic options for patients with atrial fibrillation, and offer a number of advantages over warfarin, for both the clinician and patient, including a favourable bleeding profile and convenience of use. Consideration of these new anticoagulants will improve clinical decision making
Vitamin K and Anticoagulants and Antiplatelet agents,
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Perioperative management of antithrombotic therapy in cardiovascular patients" by Nuttall MT, Rodgers GM., posted in US National Library of Medicine National Institutes of Health, found that Perioperative anticoagulation management varies depending on the indication for anticoagulation and the anticoagulant or antiplatelet agent being used by the patient. In this article, we review some of the general principles involved with perioperative anticoagulation and discuss the perioperative management of patients taking vitamin K antagonists (VKAs), bridging regimens for anticoagulants and antiplatelet agents, and strategies for managing patients on the newer oral anticoagulants.
In the study of "Perioperative management of antithrombotic therapy in cardiovascular patients" by Nuttall MT, Rodgers GM., posted in US National Library of Medicine National Institutes of Health, found that Perioperative anticoagulation management varies depending on the indication for anticoagulation and the anticoagulant or antiplatelet agent being used by the patient. In this article, we review some of the general principles involved with perioperative anticoagulation and discuss the perioperative management of patients taking vitamin K antagonists (VKAs), bridging regimens for anticoagulants and antiplatelet agents, and strategies for managing patients on the newer oral anticoagulants.
Friday, December 2, 2011
Vitamin C and Vasoactive intestinal peptide synthesis
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Effects of ascorbic acid on the vasoactive intestinal peptide synthesis in the ileum submucous plexus of normal rats" by Zanoni JN, Freitas P. posted in US National Library of Medicine National Institutes of Health, researchers found that a significant increase of the cellular profile of VIP-ergic neurons in untreated control with 210 days when compared to untreated control with 90 days. The cellular profile of VIP-ergic neurons in ascorbic acid-treated rats with 210 days was bigger than those observed in others groups.
In the study of "Effects of ascorbic acid on the vasoactive intestinal peptide synthesis in the ileum submucous plexus of normal rats" by Zanoni JN, Freitas P. posted in US National Library of Medicine National Institutes of Health, researchers found that a significant increase of the cellular profile of VIP-ergic neurons in untreated control with 210 days when compared to untreated control with 90 days. The cellular profile of VIP-ergic neurons in ascorbic acid-treated rats with 210 days was bigger than those observed in others groups.
Vitamin C and Neurotrophic effect
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Age-related changes in myosin-V myenteric neurons, CGRP and VIP immunoreactivity in the ileum of rats supplemented with ascorbic acid" by Veit AP, Zanoni JN., posted in US National Library of Medicine National Institutes of Health, researchers found that Ascorbic acid supplementation in the EA345 and EA428 groups increased the average area of myosin-V neurons by 24.6% and 24.1% compared with the E345 and E428 groups, respectively. When all groups were compared, we observed significant differences for the CGRP- and VIP-immunoractive varicosities of nerve fibers from myenteric neurons. Ascorbic acid supplementation had a neurotrophic effect on all neurons studied, suggesting a neuroprotective role.
In the study of "Age-related changes in myosin-V myenteric neurons, CGRP and VIP immunoreactivity in the ileum of rats supplemented with ascorbic acid" by Veit AP, Zanoni JN., posted in US National Library of Medicine National Institutes of Health, researchers found that Ascorbic acid supplementation in the EA345 and EA428 groups increased the average area of myosin-V neurons by 24.6% and 24.1% compared with the E345 and E428 groups, respectively. When all groups were compared, we observed significant differences for the CGRP- and VIP-immunoractive varicosities of nerve fibers from myenteric neurons. Ascorbic acid supplementation had a neurotrophic effect on all neurons studied, suggesting a neuroprotective role.
Vitamin C and Wound healing
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Oxidant and antioxidant events during epidermal growth factor therapy to cutaneous wound healing in rats" by Kalay Z, Cevher SC., posted in US National Library of Medicine National Institutes of Health, found that ascorbic acid levels and superoxide dismutase activity were measured spectrophotometrically. TBARS levels decreased and NOx levels increased on day 5 after operation, and GSH levels were increased on day 14 in EGF administered group compared with untreated group. Our data showed that EGF may act like an antioxidant by scavenging toxic oxidation products in wound tissue. In addition, it may contribute healing of the wound tissue in earlier stages and suggest a potential effective role for antioxidant therapies, especially until day 5.
In the study of "Oxidant and antioxidant events during epidermal growth factor therapy to cutaneous wound healing in rats" by Kalay Z, Cevher SC., posted in US National Library of Medicine National Institutes of Health, found that ascorbic acid levels and superoxide dismutase activity were measured spectrophotometrically. TBARS levels decreased and NOx levels increased on day 5 after operation, and GSH levels were increased on day 14 in EGF administered group compared with untreated group. Our data showed that EGF may act like an antioxidant by scavenging toxic oxidation products in wound tissue. In addition, it may contribute healing of the wound tissue in earlier stages and suggest a potential effective role for antioxidant therapies, especially until day 5.
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