Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Oxidant and antioxidant events during epidermal growth factor therapy to cutaneous wound healing in rats" by Kalay Z, Cevher SC., posted in US National Library of Medicine National Institutes of Health, found that ascorbic acid levels and superoxide dismutase activity were measured spectrophotometrically. TBARS levels decreased and NOx levels increased on day 5 after operation, and GSH levels were increased on day 14 in EGF administered group compared with untreated group. Our data showed that EGF may act like an antioxidant by scavenging toxic oxidation products in wound tissue. In addition, it may contribute healing of the wound tissue in earlier stages and suggest a potential effective role for antioxidant therapies, especially until day 5.