Thursday, December 8, 2011

Vitamin K and Testosterone production

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study of "Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells" by Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai M., posted in US National Library of Medicine National Institutes of Health, found that menaquinone-4 (MK-4, 75 mg/kg diet), one of the predominant K₂ vitamins stimulates testosterone production in rats and testis-derived tumor cells via activation of PKA. MK-4 may be involved in steroidogenesis in the testis, and its supplementation could reverse the downregulation of testosterone production in elders.

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