Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Thiamine plays a critical role in the acid tolerance of Listeria monocytogenes" by Madeo M, O'Riordan N, Fuchs TM, Utratna M, Karatzas KA, O'Byrne CP., posted in US National Library of Medicine National Institutes of Health, found that Thiamine-depleted cultures failed to produce significant concentrations of acetoin, consistent with the known thiamine dependence of acetolactate synthase, an enzyme required for acetoin synthesis from pyruvate. As acetoin synthesis is a proton-consuming process, we suggest that the acid sensitivity observed in thiamine-depleted cultures may be owing to an inability to produce acetoin.
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