According to the study of "Vitamin B6 related epilepsy during childhood' by Wang HS, Kuo MF., posted in US National Library of Medicine National Institutes of Health, researchers found thatPatients with three of the conditions respond to any form of vitamin B6. Only those with pyridoxine phosphate oxidase deficiency respond to PLP (pyridoxal-5'-phosphate) instead of pyridoxine. Interestingly, the authors have successfully treated many patients without the above four disorders using vitamin B6, and have found that the treatment was more effective with PLP than with pyridoxine, though the mechanism is not known. Since PLP is as inexpensive as pyridoxine, we suggest replacing PLP for pyridoxine when treating children with epilepsy.
Wednesday, October 19, 2011
Vitamin B6 (Pyridoxine) and Epilepsy during Childhood.
Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of "Vitamin B6 related epilepsy during childhood' by Wang HS, Kuo MF., posted in US National Library of Medicine National Institutes of Health, researchers found thatPatients with three of the conditions respond to any form of vitamin B6. Only those with pyridoxine phosphate oxidase deficiency respond to PLP (pyridoxal-5'-phosphate) instead of pyridoxine. Interestingly, the authors have successfully treated many patients without the above four disorders using vitamin B6, and have found that the treatment was more effective with PLP than with pyridoxine, though the mechanism is not known. Since PLP is as inexpensive as pyridoxine, we suggest replacing PLP for pyridoxine when treating children with epilepsy.
According to the study of "Vitamin B6 related epilepsy during childhood' by Wang HS, Kuo MF., posted in US National Library of Medicine National Institutes of Health, researchers found thatPatients with three of the conditions respond to any form of vitamin B6. Only those with pyridoxine phosphate oxidase deficiency respond to PLP (pyridoxal-5'-phosphate) instead of pyridoxine. Interestingly, the authors have successfully treated many patients without the above four disorders using vitamin B6, and have found that the treatment was more effective with PLP than with pyridoxine, though the mechanism is not known. Since PLP is as inexpensive as pyridoxine, we suggest replacing PLP for pyridoxine when treating children with epilepsy.
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