In the study of "Molecular alterations in hepatocarcinogenesis induced by dietary methyl deficiency" by Pogribny IP, James SJ, Beland FA., posted in US National Library of Medicine National Institutes of Health, researchers found that Feeding methyl-deficient diets causes several molecular alterations, including altered lipid metabolism, oxidative stress, deregulated one-carbon metabolism, and a number of epigenetic abnormalities that result in progressive liver injury culminating in the development of primary liver tumors.
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